Overdose of Modafinil

Modafinil is a wakefulness-promoting agent which was development in the 1970s in France by a neurophysiologist professor Michel Jouvet and Lafon Laboratories. The experiment originally involved the invention of a series of benzhydryl sulfinyl compounds, with Adrafinil included, which was first used in an experiment to treat narcolepsy in France 1986.  Modafinil is the major metabolite of Adrafinil. Modafinil has been a prescribed drug for the treatment of sleeping disorder in France since 1994 under the trade name Modiodal and in the US since 1998 as Provigil.

Uses of Modafinil

Modafinil is used for the treatment of sleeping disorder like narcolepsy, sleep apnea, and excessive sleeping disorder. It has off-label uses for fatigue. Studies have even shown that Modafinil can be very effective for people suffering from ADHD. Apart from that Modafinil is also used by individuals suffering from shift work disorder.

Modafinil is been marketed in the pharmaceuticals world under many trade names like Modalert, Provigil, Modvigil, Modafresh and many other.

Any medication that is been taken may have some side effects, similarly, Modafinil may cause major to minor side effects in some people. The most serious side effect Modafinil has is a rash or serious allergic reaction as Modafinil can contain a substance which may react with the individual’s body. It may also cause some mental symptoms like

  • Depression
  • hallucinations
  • an extreme increase in activity and talking
  • feeling anxious

Some of the minor side effects of Modafinil are;

  • back pain
  • headache
  • nausea
  • diarrhea
  • dizziness
  • digestion problems
  • insomnia

Inform your doctor if you experience any side effect. Some effects of Modafinil on the brain are the similar to that of other stimulants.


During taking any medication follow all the instruction given by your doctor or follow the directions on the prescribed label. Your doctor will determine the dose according to your condition. The suggestive dose of Modafinil is 200mg once a day.

A single dose early in the morning is suggested to patients suffering from narcolepsy and obstructive sleep apnea and for patients with SWD (shift work disorder) should be taken roughly around 1 hour prior to the start of their work shift.

You can take Modafinil with food and water; do not take it with alcohol.


During the studies conducted on Modafinil an experiment was carried out on mice and rats, it was found that the median lethal dose of Modafinil is just about or slightly greater than 1250mg per kg, whereas oral median lethal dose reported in rats’ ranges from 1000-3400 mg per kg. Entering by the vein in dogs it was calculated 300 mg per kg and Scientific trials on humans involving taking up to 1200 mg per kg for 7 to 12 days. An incident of acute one time overdose up to 4500 mg did not show any major or severe side effects even though a number of individuals were observed, including mental disturbance or agitation, insomnia, irritability, aggressiveness, anxiety, tremor, confusion, sleep trouble, nausea, and diarrhea.

The FDA did not found any fatal overdose involving Modafinil alone. If you have taken an overdose of Modafinil, contact your doctor or emergency care right away. Symptoms of overdose include;

  • Trouble sleeping
  • Agitation
  • Confusion
  • Feeling energized
  • Hallucinations
  • A fast or slow heartbeat
  • Chest pain

Increased blood pressure